Leukemia Supplementation Plan

About Leukemia

Leukemia is relatively rare compared to most other cancers, and is currently the 11th most common. According to the SEER 2008-2010 data, about 1.4 percent of men and women will be diagnosed with leukemia at some point during their lifetime.[1]
Although rare compared to other cancers, acute leukemia is the most common cancer among children.
The 5 year survival rate of leukemia (overall) is 57.2%.
Leukemia can be classified into 2 basic groups—the acute and the chronic leukemias. Acute types include: Acute myeloid leukemia (AML), Acute lymphoblastic leukemia (ALL), and Adult T-cell Leukemia/Lymphoma. Chronic leukemias include Chronic lymphocytic leukemia (CLL), Chronic myelogenous leukemia (CML), and Hairy Cell leukemia. Leukemia is a type of blood cancer that begins in the bone marrow and affects the white blood cells or leukocytes (which include neutrophils, basophils, eosinophils, monocytes, and lymphocytes).
Maintain a healthy body weight, as obesity can worsen the prognosis of leukemia, and increase drug resistance.[2]

Among the most well-established risk factors include:
1. A history of leukemia in the family, particularly a first degree relative.
2. Treatment for other cancers that used chemotherapy and radiation, especially as a child.
3. Additionally exposure to radiation in the environment as found in certain industries and from x-rays.[3][4]
4. Exposure to polycyclic aromatic hydrocarbons (PAHs). A human trial looked at PAH exposure and risk of childhood acute lymphoblastic leukemia (ALL) using concentrations in residential dust as an exposure indicator, and it was found that ALL risk was increased with higher exposure to PAHs.[5]
5. Leukemia occurs in clusters, which suggests that outbreaks of infections, especially in children, may be a contributing cause of the disease. It is also likely that a pre-existing immune abnormality exists, and exposure to infection is only a surrogate for immune stimulation.[6]
Other risk factors include:
1. Genetic disorders, such as Down syndrome, are associated with increased risk of leukemia.
2. Having a diagnosis of certain blood disorders, such as myelodysplastic syndromes, is associated with an increased risk of leukemia.
3. Smoking cigarettes increases the risk of several types of leukemia, and may be influenced by specific gene variants.[7][8]
Move away from areas of high radiation, such as near power plants and limit X-ray exposure.

Labs will likely be ordered by your physician to assess red and white blood cell status and platelet count.
If leukemia is suspected then a bone marrow aspiration and biopsy may be performed, which is a test that looks for malignant cells in the bone marrow as well as certain changes in the cell chromosomes from a sample of blood or bone marrow (cytogenetic analysis).
A test to look for genes that are “turned on” in several types of leukemia, such as acute myelogenous leukemia (AML) called reverse transcription-polymerase chain reaction test, or RT-PCR.
A test that compares the cancerous cells to normal blood cells to find the specific kind of leukemia, or immunophenotyping.
Incorporate regular physical activity – the risk for cardiovascular disease is increased in survivors of leukemia, but may be mitigated by regular exercise.[9][10]

1. Brightly colored, fresh vegetables, leafy greens and fresh fruits (choose organic if possible)
2. Cruciferous vegetables, such as broccoli, cauliflower, cabbage, which have high levels of DIM & isothiocyanates
3. Whole foods (foods that are as close to their natural form as possible)
4. Low sugar/low glycemic diet (Glycemic index (GI) and glycemic load (GL) are measures of the effect on blood glucose level after a food containing carbohydrates is consumed)
5. Omega-3 fatty acids, found in cold water fish such as sardines, wild-caught salmon, cod, mackerel, tuna
6. High fiber, from whole grains, beans, vegetables and fruits
7. Healthy fats, from avocados, nuts, seeds, olive oil, coconut oil, cold water fish
8. For animal protein, choose lean poultry and fish over red meat, and aim to view meat as a condiment rather than a staple. Try to choose grass fed and organic meats and eggs whenever possible. Eat no fish larger than a salmon to minimize environmental contaminants, including mercury.
1. Processed and grilled meats. Also, try to limit intake of red meat
2. Fast foods, fried foods, baked goods and packaged, processed foods
3. Sugar, sweeteners and artificial sweeteners
4. Vegetable oils, shortening, margarine and anything with hydrogenated or partially hydrogenated oils

Hemp Oil 1800 Fortified Capsules

  • Capsulesare based on SatiMedTM Botanical Formula Plus, and include an essential combination of herbal compounds from the Hemp, Cinnamon, Mint, Balm, and Chamomile plants, and are formulated in natural Hemp Seed oil.
  • Suggested dose: 2-4 capsules per day before the meal.

Omega-3 Fatty Acids

  • Omega-3 fatty acids, DHA and EPA, have been shown to exert numerous anti-cancer effects on breast cancer cells. Human studies are limited on endometrial cancer but one did recently establish that dietary PUFA and DHA inhibited endometrial cancer cell proliferation, colony formation, and migration, and promoted cell-programmed death (apoptosis) in animal and in-vitro models.[18]Additionally, GLA, another omega-3, helps to maintain balance in the fatty acids and enhances the anti-inflammatory effect.[19],[20]
  • Suggested dose: 2-3 grams combined EPA & DHA per day, with at least 1-2 grams of a GLA source.

Curcumin Phytosome

  • Derived from the spice turmeric, curcumin has multiple mechanisms of anti-cancer action. Additionally, it may enhance the effects of Bacillus Calmette-Guerin (BCG), the most commonly used agent for bladder cancer.[20][21]Doses range depending on type of curcumin, Meriva® and Longvida® have been shown to be much more efficiently absorbed forms.[22][23]
  • Suggested dose: 1-2g of Meriva® or Longvida® curcumin per day.

Diindolylmethane (DIM)

  • Diindolylmethane (DIM), extracted from cruciferous vegetables, such as broccoli, cauliflower, cabbage, etc., has been shown to induce apoptosis (programmed cell death) and reduce the invasiveness of bladder cancer cells, and may improve chemotherapeutic effectiveness against more resistant cells.[26]
  • Suggested dose: 250mg per day.

Maitake Mushroom (Beta Glucans)

  • Studies on melanoma in animal cells demonstrate powerful anti-cancer properties of the mushroom.[24]
  • Suggested dose: Capsules range from 100 to 500 mg, with at least 12-25 mg of standardized extract, 1-3 times per day.

CO Q 10 – Ubiquinol 

  • This antioxidant has been stated to improve survival rates in various forms of cancer as well as having cardioprotective influence on children with lymphoma.[31]Cell studies show that coenzyme Q 10 reduced cell activity of malignant cells in Burkitt’s lymphoma.[32]
  • Suggested dose: 100 mg per day.

Vitamin D

  • Human trials have shown that low levels of vitamin D are related to a higher risk of developing leukemia and also with a worsening prognosis following a diagnosis of AML.[11]Increased vitamin D level was associated with higher survival rate in elderly patients with acute myeloid leukemia.[12] Individuals with a history of lymphoma should also monitor 1,25 dihydroxy-vitamin D levels, as rapid conversion to this active form has been observed in patients with lymphoma.
  • Suggested dose is that sufficient to raise vitamin D blood levels to >40 ng/mL, which may require 5000 IU per day or more.[13]

Magnesium 400 FORTIFIED

  • Magnesium 400 FORTIFIED Capsules are based on SatiMedTM Botanical Formula Plus, and include an essential combination of high absorption Magnesium bisglycinate complex, Piperine and Vitamin B6.
  • Magnesium 400 FORTIFIED supports normal physiologic function, nervous system, muscles and bones, reduces tiredness and fatigue. Vitamin B-6 (pyridoxine) is important for normal brain function and for keeping the nervous system and immune system healthy.

[1] http://seer.cancer.gov/statfacts/html/leuks.html Accessed August 2014
[2] Sheng X1, Mittelman SD2. The role of adipose tissue and obesity in causing treatment resistance of acute lymphoblastic leukemia. Front Pediatr. 2014 Jun 5;2:53. doi: 10.3389/fped.2014.00053. eCollection 2014.
[3] Shih TY, Wu J, Muo CS, Kao CH. Association between leukaemia and X-ray in children: A nationwide study. J Paediatr Child Health. 2014 Aug;50(8):615-8. doi: 10.1111/jpc.12605. Epub 2014 Jun 9.
[4] Gillies M, Haylock R. The cancer mortality and incidence experience of workers at British Nuclear Fuels plc, 1946-2005. J Radiol Prot. 2014 Jul 22;34(3):595-623.
[5] Deziel NC, Rull RP, Colt JS, Reynolds P, Whitehead TP, Gunier RB, Month SR, Taggart DR, Buffler P, Ward MH, Metayer C. Polycyclic aromatic hydrocarbons in residential dust and risk of childhood acute lymphoblastic leukemia. Environ Res. 2014 Aug;133:388-95. doi: 10.1016/j.envres.2014.04.033. Epub 2014 Jun 17.
[6] Wiemels J. Perspectives on the causes of childhood leukemia. Chem Biol Interact. 2012 Apr 5;196(3):59-67. doi: 10.1016/j.cbi.2012.01.007. Epub 2012 Feb 2.
[7] Milne E1, Greenop KR, Scott RJ, et al. Parental prenatal smoking and risk of childhood acute lymphoblastic leukemia. Am J Epidemiol. 2012 Jan 1;175(1):43-53. doi: 10.1093/aje/kwr275.
[8] Lee KM1, Ward MH, Han S, et al. Paternal smoking, genetic polymorphisms in CYP1A1 and childhood leukemia risk. Leuk Res. 2009 Feb;33(2):250-8. doi: 10.1016/j.leukres.2008.06.031. Epub 2008 Aug 8.
[9] Järvelä LS1, Niinikoski H, Heinonen OJ, et al. Endothelial function in long-term survivors of childhood acute lymphoblastic leukemia: effects of a home-based exercise program. Pediatr Blood Cancer. 2013 Sep;60(9):1546-51. doi: 10.1002/pbc.24565. Epub 2013 Apr 20.
[10] Chiang J, Huang YW, Chen ML, Wang SY, Huang AC, Chen YJ. Comparison of anti-leukemic immunity against U937 cells in endurance athletes versus sedentary controls. Int J Sports Med. 2000 Nov;21(8):602-7.
[11] Lee HJ, Muindi JR, Tan W, Hu Q, Wang D, Liu S, Wilding GE, Ford LA, Sait SN, Block AW, Adjei AA, Barcos M, Griffiths EA, Thompson JE, Wang ES, Johnson CS, Trump DL, Wetzler M. Low 25(OH) vitamin D3 levels are associated with adverse outcome in newly diagnosed, intensively treated adult acute myeloid leukemia. Cancer. 2014 Feb 15;120(4):521-9. doi: 10.1002/cncr.28368. Epub 2013 Oct 25.
[12] Paubelle E, Zylbersztejn F, Alkhaeir S, Suarez F, Callens C, Dussiot M, Isnard F, Rubio MT, Damaj G, Gorin NC, Marolleau JP, Monteiro RC, Moura IC, Hermine O. Deferasirox and vitamin D improves overall survival in elderly patients with acute myeloid leukemia after demethylating agents failure. PLoS One. 2013 Jun 20;8(6):e65998. doi: 10.1371/journal.pone.0065998. Print 2013.
[13] Garland CF, French CB, Baggerly LL, et al. Vitamin D supplement doses and serum 25-hydroxyvitamin D in the range associated with cancer prevention. Anticancer Res. 2011 Feb;31(2):607-11.
[14] Espino J, González-Gómez D, Moreno D, Fernández-León MF, Rodríguez AB, Pariente JA, Delgado-Adámez J. Tempranillo-derived grape seed extract induces apoptotic cell death and cell growth arrest in human promyelocytic leukemia HL-60 cells. Food Funct. 2013 Dec;4(12):1759-66.
[15] Gao N, Budhraja A, Cheng S, Yao H, Zhang Z, Shi X. Induction of apoptosis in human leukemia cells by grape seed extract occurs via activation of c-Jun NH2-terminal kinase. Clin Cancer Res. 2009 Jan 1;15(1):140-9. doi: 10.1158/1078-0432.CCR-08-1447.
[16] Wang M, Wang L, Pan XJ, Zhang H. Monocytic differentiation of K562 cells induced by proanthocyanidins from grape seeds. Arch Pharm Res. 2012 Jan;35(1):129-35.
[17] Hu H, Qin YM. Grape seed proanthocyanidin extract induced mitochondria-associated apoptosis in human acute myeloid leukaemia 14.3D10 cells. Chin Med J (Engl). 2006 Mar 5;119(5):417-21.
[18] Shorey LE, Hagman AM, Williams DE, Ho E, Dashwood RH, Benninghoff AD. 3,3′-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells. PLoS One. 2012;7(4):e34975. doi: 10.1371/journal.pone.0034975. Epub 2012 Apr 13.
[19] Gao N, Cheng S, Budhraja A, Liu EH, Chen J, Chen D, Yang Z, Luo J, Shi X, Zhang Z. 3,3′-Diindolylmethane exhibits antileukemic activity in vitro and in vivo through a Akt-dependent process. PLoS One. 2012;7(2):e31783. doi: 10.1371/journal.pone.0031783. Epub 2012 Feb 21.
[20] Guo Y, Shan Q, Gong Y, Lin J, Shi F, Shi R, Yang X. Curcumin induces apoptosis via simultaneously targeting AKT/mTOR and RAF/MEK/ERK survival signaling pathways in human leukemia THP-1 cells. Pharmazie. 2014 Mar;69(3):229-33.
[21] Marczylo TH, Verschoyle RD, Cooke DN, et al. Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine. Cancer Chemother Pharmacol. 2007 Jul;60(2):171-7.
[22] DiSilvestro RA1, Joseph E, Zhao S, Bomser J. Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutr J. 2012 Sep 26;11:79. doi: 10.1186/1475-2891-11-79.
[23] Samet I, Han J, Jlaiel L, Sayadi S, Isoda H. Olive (Olea europaea) leaf extract induces apoptosis and monocyte/macrophage differentiation in human chronic myelogenous leukemia K562 cells: insight into the underlying mechanism. Oxid Med Cell Longev. 2014;2014:927619.
[24] Abaza L, Talorete TP, Yamada P, Kurita Y, Zarrouk M, Isoda H. Induction of growth inhibition and differentiation of human leukemia HL-60 cells by a Tunisian gerboui olive leaf extract. Biosci Biotechnol Biochem. 2007 May;71(5):1306-12.
[25] Harakeh S, Diab-Assaf M, Azar R, Hassan HM, Tayeb S, Abou-El-Ardat K, Damanhouri GA, Qadri I, Abuzenadah A, Chaudhary A, Kumosani T, Niedzwiecki A, Rath M, Yacoub H, Azhar E, Barbour E. Epigallocatechin-3-gallate inhibits tax-dependent activation of nuclear factor kappa B and of matrix metalloproteinase 9 in human T-cell lymphotropic virus-1 positive leukemia cells. Asian Pac J Cancer Prev. 2014;15(3):1219-25.
[26] Huang AC, Cheng HY, Lin TS, Chen WH, Lin JH, Lin JJ, Lu CC, Chiang JH, Hsu SC, Wu PP, Huang YP, Chung JG. Epigallocatechin gallate (EGCG), influences a murine WEHI-3 leukemia model in vivo through enhancing phagocytosis of macrophages and populations of T- and B-cells. In Vivo. 2013 Sep-Oct;27(5):627-34.
[27] Ladas EJ, Kroll DJ, Oberlies NH, Cheng B, Ndao DH, Rheingold SR, Kelly KM. A randomized, controlled, double-blind, pilot study of milk thistle for the treatment of hepatotoxicity in childhood acute lymphoblastic leukemia (ALL). Cancer. 2010 Jan 15;116(2):506-13.


Leukemia Protocol

Multiple nutritional supplements have been associated with reduced cancer incidence and/or cancer progression. This list contains those with the greatest evidence-based benefit.

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