Breast Cancer Supplementation Plan

About Breast Cancer

Nearly 270,000 new cases of breast cancer, most of which are women, are expected in 2020, with a total of nearly 42,000 deaths from the disease.[1]

Aside from skin cancer, it is the most commonly diagnosed cancer and the 2nd leading cause of cancer death among women.

Both the occurrence and death due to breast cancer have declined somewhat in recent years, largely due to a decline in hormone replacement therapy (HRT) [use among postmenopausal women.

Breast cancer is significantly influenced by dietary and lifestyle factors, in part evidenced by the nearly 3-fold higher occurrence in developed countries compared to underdeveloped ones.[2]

 

STAY ACTIVE Most studies suggest physical activity lowers breast cancer mortality.[3]

A number of risk factors are known to be associated with breast cancer occurrence, and the risk factors for younger women are not necessarily the same for women over 40.

Among the most well-established risk factors include:

  • a history of cancer in your family, particularly a first degree relative
  • having dense breast tissue

Risk factors for younger women also include:

  • current oral contraceptive use
  • not having a child until after age 30
  • having a prior benign breast biopsy[4]

Other known risk factors include:

  • alcohol intake
  • smoking
  • higher amounts of dietary fat
  • high percentage of body fat

HEALTHY DIET Consume a vegetable rich, Mediterranean-style diet, emphasizing whole foods and cruciferous vegetables (broccoli, cauliflower, kale, brussel sprouts, etc.)[5]

Mammography – Screening by mammography is recommended by a number of cancer organizations. The U.S. Preventive Services Task Force recommends individualized, informed decision making about when to start mammography.

Cancer staging and classification  Staging is the process of finding out how much cancer there is in a person’s body and where it’s located. It’s how the doctor learns the stage of a person’s cancer. Physical exams, imaging procedures, laboratory tests, pathology reports, and surgical reports provide information to determine the stage of a cancer.

Genetic evaluation – Genetic evaluation may be recommended, as a number of genetic mutations have been associated with prognosis (outlook) and help to predict how beneficial different treatments may be.

Vitamin D level – Vitamin D levels have been found to be predictive of breast cancer risk and higher grade tumors.[6][7]

RELAX Practice mindfulness-based stress reduction, like breathing techniques, yoga, Pilates and meditation.[8]

Healthy Food Options
Optimal Protein Choices: Organic/hormone-free chicken, Turkey, Grass-fed beef, Cold water fish (salmon, cod, sardines, pacific flounder/sole, butterfish, and trout. Choose wild ocean fish over farm raised fish), Organic eggs, Organic legumes (acceptable as a vegetarian protein)
Optimal Fat Choices: Flaxseed, Walnut oil, Extra virgin olive oil, Hempseed oil, Avocado, Raw, sprouted, or dry roasted nutsand seeds, Organic grass-fed butter, Ghee, Coconut oil for higher heat cooking, MCT Oil
Vegetable Choices: You can eat an unlimited amount of vegetables from the list below: Salad greens, Cruciferous vegetables (arugula, bok choy, broccoli, brussels sprouts, cabbage, cauliflower, collard greens), Carrots, Cucumbers, Sweet peppers, Raw sauerkraut, Limit starchy veggies such as potatoes
Fruit Choices: Low Glycemic Index Organic Berries (blueberries, raspberries, strawberries), Moderate Glycemic Index, (fresh or frozen), Cherries, Pears, Apricots, Melons, Plums, Oranges, Peaches, Grapefruit, Apples, Prunes, Kiwi, Nectarines, Tangerine
Beverages: Herbal teas, Naturally decaffeinated green tea, Spring water, Vegetable juices, Coconut water
Condiments: Lemon, Lime, Cayenne pepper, Sea salt, Garlic, Fresh herbs and spices
Flax/olive oil & raw apple cider vinegar for dressings
Snacks: Nuts (raw are best), Hummus, Raw or steamed vegetables, Low glycemic fruit Almond butter with apple slices

Hemp Oil 1800 Fortified Capsules

  • Capsulesare based on SatiMedTM Botanical Formula Plus, and include an essential combination of herbal compounds from the Hemp, Cinnamon, Mint, Balm, and Chamomile plants, and are formulated in natural Hemp Seed oil.
  • Suggested dose: 2-4 capsules per day before the meal.

DIM & Isothiocyanates
Isothiocyanates, which are abundant in cruciferous vegetables, like broccoli, cauliflower and cabbage, have shown anti-tumor activity and DIM (3,3′-Diindolylmethane), also found in these same vegetables, inhibits cancer cell proliferation in estrogen receptor positive and negative cells, and has shifted urinary estrogen metabolites to those with lower cancer risk among cancer survivors.[9],[10],[11]

 Suggested dose: DIM 250 mg & Isothiocyanates 600 mcg per day

Vitamin D
Vitamin D levels are associated with both the risk of breast cancer, as well as the risk of dying from it. Suggested dose is that sufficient to raise vitamin D blood levels to >40 ng/mL, which may require 5000 IU per day or more.[6]

Suggested dose: May require 5,000 IU per day or more, depending on blood levels.

Resveratrol
This antioxidant has been shown to influence the methylation of genes in women at high breast cancer risk, and to reduce the toxicity of radiation therapy.*[19],[20]

Suggested dose: 100-200 mg per day

Quercetin with Bromelain
This antioxidant has multiple mechanisms by which it inhibits breast cancer proliferation and induces apoptosis (programmed cell death), and alters the metabolism of estrogen to less toxic compounds.[23],[24] It may be particularly beneficial for Her2/neu positive cancer.[25]

Suggested dose: 200-400 mg three times per day

Multiple nutritional supplements have been associated with reduced cancer occurrence and/or cancer progression. This list contains those with the greatest evidence-base and benefit.

Hemp Oil 1800 Fortified Capsules

  • Capsulesare based on SatiMedTM Botanical Formula Plus, and include an essential combination of herbal compounds from the Hemp, Cinnamon, Mint, Balm, and Chamomile plants, and are formulated in natural Hemp Seed oil.
  • Suggested dose: 2-4 capsules per day before the meal.

Diindolylmethane (DIM)

  • DIM, abundant in cruciferous vegetables like broccoli, cauliflower and cabbage, has shown anti-tumor activity, and inhibits cancer cell proliferation in estrogen receptor positive and negative cells. DIM displays anti-estrogenic like activity by inhibiting estradiol enhanced thyroid cancer cell proliferation and in vitro metastasis associated events, namely adhesion, migration and invasion.[16],[17],[18]
  • Suggested dose: 300 mg per day.

Curcumin Phytosome

  • Cell studies researched the effects of curcumin on the cell viability, apoptosis, migration and invasion of human thyroid cancer cell lines and found that curcumin produced anti-metastatic activity. The findings project that curcumin might be an effective tumouristatic agent for the treatment of aggressive papillary thyroid carcinomas.[20],[21],[22],[23]
  • Suggested dose: 1-2 g per day of Meriva® or Longvida® curcumin.[24],[25]

Berberine

  • Human cell studies showed that co-treatment with berberine extract and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induced cell death in human renal cancer cells.[30]It has also demonstrated positive effects in animal studies with improvement to damaged kidney cells, and in human cell studies.[31],[32]
  • Suggested dose: 500 mg, 3 times per day.

Vitamin D3

  • Vitamin D levels are associated with risk of several types of cancer, including thyroid cancer. Low 25(OH) D blood levels were highly prevalent in people with solid tumors in a retrospective study of more than 30,000 individuals, despite levels infrequently being checked. [13]Individuals with a history of lymphoma should also monitor 1,25 dihydroxy-vitamin D levels, as rapid conversion to this active form has been observed.
  • Suggested dose: Suggested dose is that sufficient to raise vitamin D blood levels to >40 ng/mL, which may require 5000 IU per day or more.[14]

Magnesium 400 FORTIFIED

  • Magnesium 400 FORTIFIED Capsules are based on SatiMedTM Botanical Formula Plus, and include an essential combination of high absorption Magnesium bisglycinate complex, Piperine and Vitamin B6.
  • Magnesium 400 FORTIFIED supports normal physiologic function, nervous system, muscles and bones, reduces tiredness and fatigue. Vitamin B-6 (pyridoxine) is important for normal brain function and for keeping the nervous system and immune system healthy.

1. Maintain a healthy weight[34]
2. Most studies suggest physical activity lowers breast cancer mortality[35]
3. Avoid alcohol and smoking
4. Consume a vegetable rich, Mediterranean-style diet, emphasizing whole foods and cruciferous vegetables (broccoli, cauliflower, kale, brussel sprouts, etc.)[36]
5. Practice mindfulness-based stress reduction, like breathing techniques, yoga, Pilates and meditation[37]

[1] Chen HS, Portier K, Ghosh K, et al. Predicting US- and state-level cancer counts for the current calendar year: Part I: evaluation of temporal projection methods for mortality. Cancer. 2012;118:1091-1099.
[2] Youlden DR, Cramb SM, Dunn NA, et al. The descriptive epidemiology of female breast cancer: an international comparison of screening, incidence, survival and mortality. Cancer Epidemiol. 2012 Jun;36(3):237-48.
[3] Loprinzi PD, Cardinal BJ, Winters-Stone K, et al. Physical activity and the risk of breast cancer 1recurrence: a literature review. Oncol Nurs Forum. 2012 May 1;39(3):269-74
[4] Nelson HD, Zakher B et al. Risk factors for breast cancer for women aged 40 to 49 years: a systematic review and meta-analysis. Ann Intern Med. 2012 May 1;156(9):635-48.
[5] Voevodina O, Billich C, Arand B, et al. Association of Mediterranean diet, dietary supplements and alcohol consumption with breast density among women in South Germany: a cross-sectional study. BMC Public Health. 2013 Mar 7;13:203.
[6] Goodwin PJ, Ennis M, Pritchard KI, et al. Prognostic effects of 25-hydroxyvitamin D levels in early breast cancer. J Clin Oncol. 2009 Aug 10;27(23):3757-63.
[7] Vrieling A, Hein R, Abbas S, et al. Serum 25-hydroxyvitamin D and postmenopausal breast cancer survival: a prospective patient cohort study. Breast Cancer Res. 2011 Jul 26;13(4):R74.
[8] Carlson LE, Speca M, Patel KD, et al. Mindfulness-based stress reduction in relation to quality of life, mood, symptoms of stress and levels of cortisol, dehydroepiandrosterone sulfate (DHEAS) and melatonin in breast and prostate cancer outpatients. Psychoneuroendocrinology. 2004 May;29(4):448-74.
[9] Garland CF, French CB, Baggerly LL, et al. Vitamin D supplement doses and serum 25-hydroxyvitamin D in the range associated with cancer prevention. Anticancer Res. 2011 Feb;31(2):607-11.
[10] Alfano CM, Imayama I, Neuhouser ML, et al. Fatigue, inflammation, and ω-3 and ω-6 fatty acid intake among breast cancer survivors. J Clin Oncol. 2012 Apr 20;30(12):1280-7.
[11] Ghoreishi Z, Esfahani A, Djazayeri A, et al. Omega-3 fatty acids are protective against paclitaxel-induced peripheral neuropathy: a randomized double-blind placebo controlled trial. BMC Cancer. 2012 Aug 15;12:355.
[12] Xu Y, Qian SY1. Anti-cancer activities of ω-6 polyunsaturated fatty acids. Biomed J. 2014 May-Jun;37(3):112-9.
[13] Biomed J. 2014 May-Jun;37(3):112-9. Gamma linolenic acid with tamoxifen as primary therapy in breast cancer. Int J Cancer. 2000 Mar 1;85(5):643-8.
[14] Gupta P, Srivastava SK. Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models. BMC Med. 2012 Jul 24;10:80.
[15] Jin Y. 3,3′-Diindolylmethane inhibits breast cancer cell growth via miR-21-mediated Cdc25A degradation. Mol Cell Biochem. 2011 Dec;358(1-2):345-54.
[16] Dalessandri KM, Firestone GL, et al. Pilot study: effect of 3,3′-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Cancer. 2004;50(2):161-7.
[17] Perez AT, Arun B, Tripathy D, et al. A phase 1B dose escalation trial of Scutellaria barbata (BZL101) for patients with metastatic breast cancer. Breast Cancer Res Treat. 2010 Feb;120(1):111-8.
[18] Klawitter J, Klawitter J, Gurshtein J, et al. Bezielle (BZL101)-induced oxidative stress damage followed by redistribution of metabolic fluxes in breast cancer cells: a combined proteomic and metabolomic study. Int J Cancer. 2011 Dec 15;129(12):2945-57.
[19] Royt M, Mukherjee S, Sarkar R, et al. Curcumin sensitizes chemotherapeutic drugs via modulation of PKC, telomerase, NF-kappaB and HDAC in breast cancer. Ther Deliv. 2011 Oct;2(10):1275-93.
[20] Bayet-Robert M, Kwiatkowski F, Leheurteur M, et al. Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer. Cancer Biol Ther. 2010 Jan;9(1):8-14. Epub 2010 Jan 21.
[21] Marczylo TH, Verschoyle RD, Cooke DN, et al. Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine. Cancer Chemother Pharmacol. 2007 Jul;60(2):171-7.
[22] DiSilvestro RA1, Joseph E, Zhao S, Bomser J. Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutr J. 2012 Sep 26;11:79. doi: 10.1186/1475-2891-11-79.
[23] Zhang G, Wang Y, Zhang Y, et al. Anti-cancer activities of tea epigallocatechin-3-gallate in breast cancer patients under radiotherapy. Curr Mol Med. 2012 Feb;12(2):163-76.
[24] Eddy SF, Kane SE, Sonenshein GE. Trastuzumab-resistant HER2-driven breast cancer cells are sensitive to epigallocatechin-3 gallate. Cancer Res. 2007 Oct 1;67(19):9018-23.
[25] Zhu W, Qin W, Zhang K, et al. Trans-resveratrol alters mammary promoter hypermethylation in women at increased risk for breast cancer. Nutr Cancer. 2012 Apr;64(3):393-400.
[26] Di Franco R, Calvanese M, Murino P, et al. Skin toxicity from external beam radiation therapy in breast cancer patients: protective effects of Resveratrol, Lycopene, Vitamin C and anthocianin (Ixor®). Radiat Oncol. 2012 Jan 30;7:12.
[27] Kim S, Kim SH, Hur SM, et al. Silibinin prevents TPA-induced MMP-9 expression by down-regulation of COX-2 in human breast cancer cells. J Ethnopharmacol. 2009 Nov 12;126(2):252-7.
[28] Tyagi AK, Agarwal C, Chan DC, et al. Synergistic anti-cancer effects of silibinin with conventional cytotoxic agents doxorubicin, cisplatin and carboplatin against human breast carcinoma MCF-7 and MDA-MB468 cells. Oncol Rep. 2004 Feb;11(2):493-9.
[29] Duo J, Ying GG, Wang GW, et al. Quercetin inhibits human breast cancer cell proliferation and induces apoptosis via Bcl-2 and Bax regulation. Mol Med Rep. 2012 Jun;5(6):1453-6.
[30] Mense SM, Chhabra J, Bhat HK. Preferential induction of cytochrome P450 1A1 over cytochrome P450 1B1 in human breast epithelial cells following exposure to quercetin. J Steroid Biochem Mol Biol. 2008 May;110(1-2):157-62.
[31] Seo HS, Choi HS, Choi HS, et al. Phytoestrogens induce apoptosis via extrinsic pathway, inhibiting nuclear factor-kappaB signaling in HER2-overexpressing breast cancer cells. Anticancer Res. 2011 Oct;31(10):3301-13.
[32] Song X, Siriwardhana N, et al. Grape seed proanthocyanidin suppression of breast cell carcinogenesis induced by chronic exposure to combined 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene. Mol Carcinog. 2010 May;49(5):450-63.
[33] Kijima I, Phung S, Hur G, et al. Grape seed extract is an aromatase inhibitor and a suppressor of aromatase expression. Cancer Res. 2006 Jun 1;66(11):5960-7.
[34] Cutando A, López-Valverde A, et al. Role of melatonin in cancer treatment. Anticancer Res. 2012 Jul;32(7):2747-53.
[35] Ju J, Picinich SC, Yang Z, et al. Cancer-preventive activities of tocopherols and tocotrienols. Carcinogenesis. 2010 Apr;31(4):533-42.
[36] Yang CS, Suh N, Kong AN. Does vitamin E prevent or promote cancer? Cancer Prev Res (Phila). 2012 May;5(5):701-5.
[37] Nimptsch K, Rohrmann S, Kaaks R, et al. Dietary vitamin K intake in relation to cancer incidence and mortality: results from the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg). Am J Clin Nutr. 2010 May;91(5):1348-58.
[38] Nimptsch K, Rohrmann S, Linseisen J. Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg). Am J Clin Nutr. 2008 Apr;87(4):985-92.
[39] Zhang H, Ozaki I, Hamajima H, et al. Vitamin K2 augments 5-fluorouracil-induced growth inhibition of human hepatocellular carcinoma cells by inhibiting NF-κB activation. Oncol Rep. 2011 Jan;25(1):159-66.

 

Breast Cancer Protocol

Multiple nutritional supplements have been associated with reduced cancer incidence and/or cancer progression. This list contains those with the greatest evidence-based benefit.

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