Non-Hodgkin’s Lymphoma (NHL) is the most common type of lymphoma. Hodgkin’s lymphoma is less common, and has a slightly higher cure rate. According to SEER data, in 2011 there were 530,919 people living with NHL in the United States. There has been a 73 percent rise between 1973 and 1991 in NHL with continued increases ever since.
Approximately 2.1 percent of men and women will be diagnosed with non-Hodgkin lymphoma at some point during their lifetime, based on 2008-2010 SEER data, and the 5 year survival rate is 69.3%.
The survival rate for lymphoma has greatly increased in the past 40 years, especially in children. The five-year relative survival rate for NHL patients has risen from 31 percent in Caucasians from 1960 to 1963 to 71.2 percent for all races from 2003 to 2009. In youths under 20, the 5 year survival rate is 84.5%, which is a significant improvement since most youths did not survive 5 years in the 1970s. NHL and Hodgkin lymphoma account for 11% of total cancer diagnoses in children.
Some of the many subtypes of NHL include: B cell and T cell types , follicular lymphoma, cutaneous lymphoma, marginal zone lymphoma, mantle cell lymphoma, Burkitt’s lymphoma, and lymphoblastic lymphoma . Lymphoplasmacytic lymphoma is a related lymphoma also known as Waldenstrom’s macroglobulinemia. Other lymphomas may be named for their site of presentation, such as CNS lymphoma.
BREAK UNHEALTHY HABITS
Do not smoke, especially if you have hepatitis C. Heavy smoking doubles the risk of having NHL. Hepatitis C positive individuals who are heavy smokers have a nearly 4-fold higher risk of developing non-Hodgkin lymphoma than non-smokers.
A number of risk factors are known to be associated with lymphoma. Among the most well-established risk factors include:
1. Being of Caucasian race and male gender in the United States.
2. Aging is a major risk factor for most lymphomas although there are some types that occur more commonly in childhood.
3. Exposure to environmental radiation or being treated with radiation and chemotherapy for other diseases significantly increases the risk of lymphoma.
4. Having HIV or other immune system problems, including other cancers and viral infections such as CMV and EBV, increases the risk. Infection with hepatitis C nearly doubles the risk of NHL.
Other risk factors include:
1. Obesity and high BMI has been found to be a predictor of worse outcomes specifically for chronic lymphocytic leukemia and small lymphocytic lymphoma (vs. diffuse large B cell lymphoma and follicular lymphoma).
2. Pesticide and herbicide exposure. Human studies are demonstrating that exposure to pesticides increases the risk of NHL, especially in individuals who work and live on or near farms. Specifically, diffuse large B-cell lymphoma was positively associated with phenoxy herbicide exposure. Glyphosate is a major concern with lymphoma risk.Additionally, home pesticide use has been associated with a several fold increase in risk for NHL in children.
3. A number of genetic variants have been associated with risk, particularly when combined with environmental toxin exposure.
4. Smoking, alcohol use and sedentary lifestyle
5. Autoimmune disease: a number of autoimmune diseases have been associated with a higher risk of NHL, although the absolute risk is still small.
Meditation, stress relief, yoga and other modalities to reduce overall stress emotionally and physically have positive effects on lymphoma.
A biopsy of the swollen lymph node (s) is recommended and is often preceded by imaging of the body part affected, which can include x-ray, ultrasound, positron emission tomography (PET) computed tomography (CT) or MRI. Once the disease has been detected, other testing of the cancer cells includes cytogenetics and flow cytometry, as well as PET/CT.
Blood testing assesses white and red blood cells (RBC, CBC) and liver function are also routinely part of the diagnosis and monitoring of lymphomas
Exercise is a well-established way to prevent cancer development, including lymphoma. One study found that women who sat for 6 hours a day had a 28% higher risk of NHL than those who sat for 3 hours per day.
1. Cruciferous vegetables, such as broccoli, cauliflower, cabbage, contain DIM and I3C.
2. Whole foods (foods that are as close to their natural form as possible)
3. Low sugar/low glycemic diet (Glycemic index (GI) and glycemic load (GL) are measures of the effect on blood glucose level after a food containing carbohydrates is consumed)
4. Omega-3 fatty acids, found in cold water fish such as sardines, wild-caught salmon, cod, mackerel, tuna
5. High fiber, from whole grains, beans, vegetables and fruits
6. Healthy fats, from avocados, nuts, seeds, olive oil, coconut oil, cold water fish
7. For animal protein, choose lean poultry and fish over red meat, and aim to view meat as a condiment rather than a staple. Try to choose grass fed and organic meats and eggs whenever possible. Eat no fish larger than a salmon to minimize environmental contaminants, including mercury.
1. Foods that have been treated with pesticides and herbicides, especially glyphosate
2. Processed and grilled meats. Also, try to limit intake of red meat
3. Fast foods, fried foods, baked goods and packaged, processed foods
4. Sugar, sweeteners and artificial sweeteners
5. Vegetable oils, shortening, margarine and anything with hydrogenated or partially hydrogenated oils
Hemp Oil 1800 Fortified Capsules
- Capsulesare based on SatiMedTM Botanical Formula Plus, and include an essential combination of herbal compounds from the Hemp, Cinnamon, Mint, Balm, and Chamomile plants, and are formulated in natural Hemp Seed oil.
- Suggested dose: 2-4 capsules per day before the meal.
- This antioxidant has been stated to improve survival rates in various forms of cancer as well as having cardioprotective influence on children with lymphoma.Cell studies show that coenzyme Q 10 reduced cell activity of malignant cells in Burkitt’s lymphoma.
- Suggested dose: 100 mg per day.
- Diindolylmethane (DIM), extracted from cruciferous vegetables, such as broccoli, cauliflower, cabbage, etc., has been shown to induce apoptosis (programmed cell death) and reduce the invasiveness of bladder cancer cells, and may improve chemotherapeutic effectiveness against more resistant cells.
- Suggested dose: 250mg per day.
- The active extract from the spice turmeric, curcumin has high anti-cancer effects on many cell lines, including lymphoma. Curcumin inhibited the growth of HL cell lines and increased the sensitivity to the chemotherapy cisplatin.Lymphoma tumor growth in mice was inhibited by curcumin.,
- Suggested dose: 1-2g per day of Meriva® or Longvida® curcumin.,
- This antioxidant found in red wine and grapes inhibited Epstein Barr Virus (EBV) in Burkitt’s lymphoma cells.Additionally it induced cell death in Hodgkin lymphoma.
- Suggested dose: 100-200mg per day.
Maitake Mushroom (Beta Glucans)
- Studies on melanoma in animal cells demonstrate powerful anti-cancer properties of the mushroom.
- Suggested dose: Capsules range from 100 to 500 mg, with at least 12-25 mg of standardized extract, 1-3 times per day.
- Human trials have shown that low levels of vitamin D are related to a higher risk of developing leukemia and also with a worsening prognosis following a diagnosis of AML.Increased vitamin D level was associated with higher survival rate in elderly patients with acute myeloid leukemia. Individuals with a history of lymphoma should also monitor 1,25 dihydroxy-vitamin D levels, as rapid conversion to this active form has been observed in patients with lymphoma.
- Suggested dose is that sufficient to raise vitamin D blood levels to >40 ng/mL, which may require 5000 IU per day or more.
- Magnesium 400 FORTIFIED Capsules are based on SatiMedTM Botanical Formula Plus, and include an essential combination of high absorption Magnesium bisglycinate complex, Piperine and Vitamin B6.
- Magnesium 400 FORTIFIED supports normal physiologic function, nervous system, muscles and bones, reduces tiredness and fatigue. Vitamin B-6 (pyridoxine) is important for normal brain function and for keeping the nervous system and immune system healthy.
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