Lung and Bronchus Cancer Supplementation Plan

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About Lung Cancer

Lung and bronchus cancer is the leading cause of cancer death in the United States, with over 225,000 new diagnoses in 2012, and an estimated 87,750 and 72,590 deaths predicted to occur in men and women, respectively. This is nearly as many cancer deaths and prostate, breast, and colon cancer combined.
85% of all cases are non-small cell lung cancer (NSCLC), with most patients diagnosed after the disease has advanced.
Lung cancer has a mortality rate that has changed very little, getting slightly worse over the last 40 years.[1]
In the United States 85-90% of all cases are due to tobacco smoking, making this a very preventable condition.
HEALTHY DIET
Eat a plant-rich diet, with diverse fruits and vegetable, emphasizing cruciferous (broccoli, cauliflower, kale) and colorful fruits and vegetables, and flavonoid rich foods (citrus, dark chocolate, tea).[2][3]

Smoking increases the risk for lung cancer by a factor of 10-30 fold compared to “never-smokers.”
Second-hand smoke is also thought to contribute to nearly 20% of lung cancer cases among non-smokers, raising lung cancer risk approximately 30% versus those with no exposure.[4]
Because smoking is responsible for such a large percentage of lung cancer cases, it is often ignored that non-smoking causes of lung cancer are still one of the top 10 causes of cancer mortality.[5] This includes occupational exposure to known lung carcinogens, such as asbestos, arsenic, nickel, and radon, as well as environmental air pollution, such as that caused by fossil fuel combustion.
Dietary factors also influence the risk of lung cancer, as diets higher in fruits and vegetables are protective, especially cruciferous vegetables such as broccoli, cauliflower, cabbage, kale, etc.[6]
ENVIRONMENT MATTERS
Avoid exposure to environmental toxins – air pollution, radon, wood smoke, etc.

Screening CT scans – May be of benefit for those at high risk, such as older individuals with a long history of smoking.
Imaging – Including CT, MRI, and positron emission tomography Likely be used to monitor treatment efficacy and detection of recurrence.[7]
Vitamin D levels – Vitamin D levels have been associated with both risk of developing lung cancer and survival among lung cancer patients.[8]
C-reactive protein levels – Elevated C-reactive protein levels have been associated with a greater risk of early death, and may help guide appropriate anti-inflammatory treatments.[9]
STAY ACTIVE
Be physically active – this has been shown to be associated with a better quality of life among lung cancer patients.[10]

Emphasize:
1. Brightly colored, fresh vegetables, leafy greens and fresh fruits (choose organic if possible)
2. Cruciferous vegetables, such as broccoli, cauliflower, cabbage, which have high levels of DIM & isothiocyanates
3. Whole foods (foods that are as close to their natural form as possible)
4. Low sugar/low glycemic diet (Glycemic index (GI) and glycemic load (GL) are measures of the effect on blood glucose level after a food containing carbohydrates is consumed)
5. Omega-3 fatty acids, found in cold water fish such as sardines, wild-caught salmon, cod, mackerel, tuna
6. High fiber, from whole grains, beans, vegetables and fruits
7. Healthy fats, from avocados, nuts, seeds, olive oil, coconut oil, cold water fish
8. For animal protein, choose lean poultry and fish over red meat, and aim to view meat as a condiment rather than a staple. Try to choose grass fed and organic meats and eggs whenever possible. Eat no fish larger than a salmon to minimize environmental contaminants, including mercury.
Avoid:
1. Processed and grilled meats. Also, try to limit intake of red meat
2. Fast foods, fried foods, baked goods and packaged, processed foods
3. Sugar, sweeteners and artificial sweeteners
4. Vegetable oils, shortening, margarine and anything with hydrogenated or partially hydrogenated oils

Hemp Oil 1800 Fortified Capsules

  • Capsulesare based on SatiMedTM Botanical Formula Plus, and include an essential combination of herbal compounds from the Hemp, Cinnamon, Mint, Balm, and Chamomile plants, and are formulated in natural Hemp Seed oil.
  • Suggested dose: 2-4 capsules per day before the meal.

Omega-3 Fatty Acids

  • Clinical trials with the omega-3 fatty acids, EPA and DHA, have shown improved nutritional status, better functional status, reduced inflammation, and improved effectiveness of chemotherapeutic agents.[12],[13],[14]Additionally, GLA, another omega-3 found in Evening Primrose oil, helps to maintain balance in the fatty acids and enhances the anti-inflammatory effect.[15],[16]
  • Suggested dose: 2-3 grams combined EPA & DHA per day, with at least 1-2 grams of a GLA source.

Cellular Pro

  • Cellular Pro provides pterostilbene, a methylated resveratrol that occurs naturally in berries. This formula also contains resveratrol, curcumin and vitamin D3 , which compliment pterostilbene in supporting metabolic health. Ptersotilbene targets PPAR alpha, which plays important roles in lipid metabolism. Reserveratrol supports mitochondrial function by promoting the actions of SIRT1, a cellular enzyme that contributes to healthy aging.*
  • Suggested usage:As a dietary supplement, adults take 1 capsule daily.

Quercetin

  • A high intake of this antioxidant has been associated with a reduced risk of developing lung cancer, as it appears to influence several anti-proliferative pathways.[26],[27]
  • Suggested dose: 200-400mg, three times per day.

Pterostilbene & Resveratrol

  • Found in red wine and grapes, this antioxidant inhibits the invasion and metastasis of lung cancer cells.[25]
  • Suggested dose: 100-200mg per day.

Vitamin D

  • Lower levels of vitamin D have been associated with an increased risk for developing lung cancer as well as lung cancer death.
  • Suggested dose is that sufficient to raise vitamin D blood levels to >40 ng/mL, which may require 5000 IU per day or more.[11]

Magnesium 400 FORTIFIED

  • Magnesium 400 FORTIFIED Capsules are based on SatiMedTM Botanical Formula Plus, and include an essential combination of high absorption Magnesium bisglycinate complex, Piperine and Vitamin B6.
  • Magnesium 400 FORTIFIED supports normal physiologic function, nervous system, muscles and bones, reduces tiredness and fatigue. Vitamin B-6 (pyridoxine) is important for normal brain function and for keeping the nervous system and immune system healthy.

 

[1] Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. 2012 Jan-Feb;62(1):10-29.
[2] Wright M.E., Park Y., Subar A.F.,et al: Intakes of fruit, vegetables, and specific botanical groups in relation to lung cancer risk in the NIH-AARP Diet and Health Study. Am J Epidemiol 2008; 168: 1024-1034.
[3] Christensen KY, Naidu A, Parent MÉ, et al. The risk of lung cancer related to dietary intake of flavonoids. Nutr Cancer. 2012;64(7):964-74.
[4] Dela Cruz CS, Tanoue LT, et al. Lung cancer: epidemiology, etiology, and prevention. Clin Chest Med. 2011 Dec;32(4):605-44.
[5] Field RW, Withers BL. Occupational and environmental causes of lung cancer. Clin Chest Med. 2012 Dec;33(4):681-703.
[6] Brennan P, Hsu CC, Moullan N, et al. Effect of cruciferous vegetables on lung cancer in patients stratified by genetic status: a mendelian randomisation approach. Lancet. 2005 Oct 29-Nov 4;366(9496):1558-60.
[7] Erasmus JJ, Sabloff BS. CT, positron emission tomography, and MRI in staging lung cancer. Clin Chest Med. 2008 Mar;29(1):39-57, v.
[8] Tretli S, Schwartz GG, et al. Serum levels of 25-hydroxyvitamin D and survival in Norwegian patients with cancer of breast, colon, lung, and lymphoma: a population-based study. Cancer Causes Control. 2012 Feb;23(2):363-70.
[9] Allin KH, Nordestgaard BG. Elevated C-reactive protein in the diagnosis, prognosis, and cause of cancer. Crit Rev Clin Lab Sci. 2011 Jul-Aug;48(4):155-70.
[10] Solberg Nes L, Liu H, Patten CA, et al. Physical activity level and quality of life in long term lung cancer survivors. Lung Cancer. 2012 Sep;77(3):611-6.
[11] Garland CF, French CB, Baggerly LL, et al. Vitamin D supplement doses and serum 25-hydroxyvitamin D in the range associated with cancer prevention. Anticancer Res. 2011 Feb;31(2):607-11.
[12] Finocchiaro C, Segre O, Fadda M, et al. Effect of n-3 fatty acids on patients with advanced lung cancer: a double-blind, placebo-controlled study. Br J Nutr. 2012 Jul;108(2):327-33.
[13] van der Meij BS, Langius JA, et al. Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT. Eur J Clin Nutr. 2012 Mar;66(3):399-404.
[14] Murphy RA, Mourtzakis M, Chu QS, et al. Supplementation with fish oil increases first-line chemotherapy efficacy in patients with advanced nonsmall cell lung cancer. Cancer. 2011 Aug 15;117(16):3774-80.
[15] Xu Y, Qian SY1. Anti-cancer activities of ω-6 polyunsaturated fatty acids. Biomed J. 2014 May-Jun;37(3):112-9.
[16] Biomed J. 2014 May-Jun;37(3):112-9. Gamma linolenic acid with tamoxifen as primary therapy in breast cancer. Int J Cancer. 2000 Mar 1;85(5):643-8.
[17] Choi SY, Yu JH, Kim H. Mechanism of alpha-lipoic acid-induced apoptosis of lung cancer cells. Ann N Y Acad Sci. 2009 Aug;1171:149-55.
[18] Mantovani G, Macciò A, Melis G, et al. Restoration of functional defects in peripheral blood mononuclear cells isolated from cancer patients by thiol antioxidants alpha-lipoic acid and N-acetyl cysteine. Int J Cancer. 2000 Jun 15;86(6):842-7.
[19] Lambert JD, Sang S, Yang CS. N-Acetylcysteine enhances the lung cancer inhibitory effect of epigallocatechin-3-gallate and forms a new adduct. Free Radic Biol Med. 2008 Mar 15;44(6):1069-74.
[20] De Flora S, Izzotti A, D’Agostini F, et al. Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points. Carcinogenesis. 2001 Jul;22(7):999-1013.
[21] Suganuma M, Saha A, Fujiki H. New cancer treatment strategy using combination of green tea catechins and anticancer drugs. Cancer Sci. 2011 Feb;102(2):317-23.
[22] Yin H, Guo R, Xu Y, et al. Synergistic antitumor efficiency of docetaxel and curcumin against lung cancer. Acta Biochim Biophys Sin (Shanghai). 2012 Feb;44(2):147-53.
[23] Marczylo TH, Verschoyle RD, Cooke DN, et al. Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine. Cancer Chemother Pharmacol. 2007 Jul;60(2):171-7.
[24] DiSilvestro RA1, Joseph E, Zhao S, Bomser J. Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutr J. 2012 Sep 26;11:79. doi: 10.1186/1475-2891-11-79.
[25] Kim YS, Sull JW, Sung HJ, et al. Suppressing effect of resveratrol on the migration and invasion of human metastatic lung and cervical cancer cells. Mol Biol Rep. 2012 Sep;39(9):8709-16.
[26] Lam TK, Rotunno M, Lubin JH, et al. Dietary quercetin, quercetin-gene interaction, metabolic gene expression in lung tissue and lung cancer risk. Carcinogenesis. 2010 Apr;31(4):634-42.
[27] Zheng SY, Li Y, et al. Anticancer effect and apoptosis induction by quercetin in the human lung cancer cell line A-549. Mol Med Rep. 2012 Mar;5(3):822-6.
[28] Cutando A, López-Valverde A, et al. Role of melatonin in cancer treatment. Anticancer Res. 2012 Jul;32(7):2747-53.
[29] Lissoni P, Chilelli M, Villa S, et al. Five years survival in metastatic non-small cell lung cancer patients treated with chemotherapy alone or chemotherapy and melatonin: a randomized trial. J Pineal Res. 2003 Aug;35(1):12-5.
[30] Ju J, Picinich SC, Yang Z, et al. Cancer-preventive activities of tocopherols and tocotrienols. Carcinogenesis. 2010 Apr;31(4):533-42.
[31] Yang CS, Suh N, Kong AN. Does vitamin E prevent or promote cancer? Cancer Prev Res (Phila). 2012 May;5(5):701-5
[32] Nimptsch K, Rohrmann S, Kaaks R, et al. Dietary vitamin K intake in relation to cancer incidence and mortality: results from the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg). Am J Clin Nutr. 2010 May;91(5):1348-58.
[33] Nimptsch K, Rohrmann S, Linseisen J. Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg). Am J Clin Nutr. 2008 Apr;87(4):985-92.
[34] Zhang H, Ozaki I, Hamajima H, et al. Vitamin K2 augments 5-fluorouracil-induced growth inhibition of human hepatocellular carcinoma cells by inhibiting NF-κB activation. Oncol Rep. 2011 Jan;25(1):159-66.

 

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